Evaluation of oxprenolol and metoprolol Oros systems in the dog: Comparison of in vivo and in vitro drug release, and of drug absorption from duodenal and colonic infusion sites

摘要

1 The performance of oxprenolol and metoprolol Oros® systems has been evaluated in the dog. One study compared in vivo and in vitro release from both systems over 2-14 h. The other compared the systemic availabilities of both drugs after 3 h infusion at a constant rate into the cephalic and hepatic portal veins, and into the lumen of the duodenum and colon.